李基棕
李基棕，博士，研究员。南京农业大学硕士生导师，江苏大学硕士生导师，临沂大学兼职教授，国家科技部科技专家库入库专家，教育部学位论文评议专家，江苏省免疫学会理事。
主要从事动物重要疫病的病原学、致病机制与免疫防控技术研究。近年来，主持国家自然科学基金青年基金和面上项目各1项，十四五重点研发计划子课题1项，江苏省自然科学基金青年基金和面上项目各1项，江苏省农业科技自主创新资金项目1项，山东省自然科学基金1项，农业农村部禽流感等家禽重大疾病防控、省重点实验室开放课题1项，江苏省科技副总项目1项。以第一作者或通讯作者在Journal of Virology、Advanced Healthcare Materials、Frontiers in Immunology、Veterinary Microbiology、Virology、Frontiers in Microbiology、Frontiers in Cellular and Infection Microbiology Archives of Virology等杂志发表SCI论文30余篇。Veterinary Microbiology、Transboundary an Emerging Diseases、BMC Veterinary Research、Infection Genetics and Evolution、Microbial Pathogenesis等杂志审稿人。研究成果获得江苏省科技进步奖，江苏省农学会科技奖，江苏省畜牧兽医学会科技奖，江苏省农业科学院科学技术奖，大北农科技奖。
联系电话：025-84390988 电子邮箱：lijizong22@sina.com
一、主要承担课题
1. 主持国家自然科学基金面上项目：PDCoV下调ST6GALNAC1抑制MUC2唾液酸化破坏肠道黏液层的分子机制，2025.1-2028.12，项目编号：32473119。
2. 主持江苏省农业科技自主创新资金项目：猪重要疫病新型疫苗产品创制，2024.7-2027.6，项目编号：CX(24)2001。
3. 主持江苏省自然科学基金面上项目，猪δ冠状病毒促进C3蛋白表达增强其致病作用的分子机制，2022.7-2025.6，项目编号：BK20221432。
4.主持重点研发计划子课题：牛冠状病毒的流行传播特征与遗传演化规律研究，2021.12-2024.11，项目编号：2021YFD1801101。
5. 主持国家自然科学基金青年基金：MiR-222调控Ⅰ型干扰素抑制山羊副流感病毒3型复制的分子机制研究，2018.1-2020.12，项目编号：31702272。
6. 主持江苏省自然科学基金青年基金，Bta-miR-222调控Ⅰ型干扰素影响山羊副流感病毒3型复制的分子机制，2017.7-2020.6，项目编号：BK20170595。
7. 主持山东省自然科学基金培养基金，外源性一氧化氮调控猪圆环病毒2型复制的机制，2016.11-2018.6，项目编号：2016ZRB01AH2。
8. 主持农业农村部禽流感等家禽重大疾病防控、省重点实验室开放课题，猪德尔塔冠状病毒的病毒样颗粒疫苗研制，2022.10-2024.9，项目编号：YDWS202213。
9. 江苏省科技副总项目，江苏省科学技术厅，2020/8-2023/7，项目编号：FZ20200430。
10. 主持合作研发项目“猪腹泻相关疫苗的研发”，2022.3-2032.3。
二、主要科研成果
（一）代表论文
1. Liyuan Fan1, Xin Yi1, Chunyan Zhong, Chuangye Yang, Ziyi Niu, Xiaofeng Xue, Wei Wang, Rongli Guo, Jiale Ma, Yinhe Zha, Jianhong Shu, Jizong Li*, Bin Li*. A trivalent enteric coronaviruses inactivated vaccine provides effective protection against PEDV, TGEV, and PDCoV[J]. Veterinary Microbiology, 2025, 308: 110630.
2. Jizong Li1, Li Xiao1, Zhuoqi Chen, Liyuan Fan, Wei Wang, Rongli Guo, Zhaoming He, Hongpeng Hu, Jianhao Jiang, Lixiang Zhao*, Tianyi Zhong*, Baochao Fan, Xing Zhu, Bin Li*. A spike-based mRNA vaccine that induces durable and broad protection against porcine deltacoronavirus in piglets[J]. Journal of Virology, 2024, (19): e0053524.
3. Jizong Li1, Jian Zhou1, Tianyi Zhang, Heyong Wu, Feng Li, Chunyun Qi, Liyuan Fan, Xuesong Yuan, Wei Wang, Rongli Guo, Baochao Fan, Xiaochun Tang, Daxin Pang, Hongsheng Ouyang, Zicong Xie*, Bin Li*. Effective inhibition of PDCoV infection in chimeric APN gene-edited neonatal pigs[J]. Journal of Virology, 2024, 98(8): e0061124.
4. Lili Ren, Chengcheng Ouyang, Shuqing Zhao, Qiqi Zheng, Weiu Guo, Baochao Fan, Jinzhu Zhou, Wei Zhang, Mi Hu, Jizong Li*，Bin Li*. A novel polymer nanoparticle Polydimethyl diallyl ammonium chloride as an adjuvant enhances the immune response of SARS-CoV-2 subunit vaccine[J]. Advanced Healthcare Materials, 2024, 13(15): e2304575.
5. Zhuoqi Chen1, Chunyan Zhong1, Liyuan Fan, Hongqi Shang, Li Xiao, Wei Wang, Rongli Guo, Baochao Fan, Jizong Li*, Bin Li*. Nonstructural protein 14 of PDCoV promotes complement C3 expression via the activation of p38-MAPK-C/EBP pathway[J]. Veterinary Microbiology, 2024, 295: 110137.
6. Zhuoqi Chen1, Li Xiao1, Jinzhu Zhou, Wei Wang, Rongli Guo, Jizong Li*, Bin Li*. A new S1 subunit truncation vaccine induces effective protection against porcine deltacoronavirus in suckling piglets[J]. Veterinary Microbiology, 2024, 299: 110303.
7. Baotai Zhang1, Siyuan Li1, Jinzhu Zhou, Wei Wang, Li Xiao, Xuesong Yuan, Xin Yi , Liyuan Fan, Baochao Fan, Xing Zhu, Jizong Li*, Bin Li*. A novel virus-like particles vaccine induces broad immune protective against deltacoronavirus in piglets[J]. Virology, 2024, 597: 110150.
8. Baotai Zhang1, Siyuan Li1, Zhuoqi Chen, Liyuan Fan, Wei Wang, Rongli Guo, Baochao Fan, Jizong Li*, Bin Li*. Phosphorylation of G3BP1 is involved in the regulation of PDCoV-induced inflammatory response[J]. Veterinary Microbiology, 2024, 293: 110070.
9. Liyuan Fan1, Wei Wang1, Xin Yi1, Xuesong Yuan, Zhuoqi Chen, Li Xiao, Chunyu Lu, Rongli Guo, Baochao Fan, Jiale Ma, Yinhe Zha, Jianhong Shu, Jizong Li*, Bin Li*. An inactivated PDCoV vaccine induces robust neutralizing antibodies and immune protection in pigs lasting for three months[J]. Microbial Pathogenesis, 2024, 192: 106714.
10. Siyuan Li1, Jin Huang1, Xuhang Cai, Li Mao, Lingling Xie, Fu Wang, Hua Zhou, Xuesong Yuan, Xincheng Fu, Baochao Fan, Xingang Xu*, Jizong Li*, Bin Li*. The prevalence and evolutionary characteristics of bovine coronavirus in China[J]. Veterinary Sciences, 2024, 11(6): 230.
11. Siyuan Li1, Xuesong Yuan, Xuhang Cai, Li Mao, Xingang Xu, Jizong Li*, Bin Li*. An emerging bovine coronavirus with a 3-amino-acid deletion in N gene caused serious diseases in both respiratory and digestive tract[J]. Frontiers in Microbiology, 2024.
12. Wei Wang, Baochao Fan, Xuehan Zhang, Shanshan Yang, Junming Zhou, Rongli Guo, Yongxiang Zhao, Jinzhu Zhou, Jizong Li*, Bin Li*. Development and evaluation of a monoclonal antibody-based competitive ELISA for detecting porcine deltacoronavirus antibodies[J]. Animal Diseases, 2024, 4:30.
13. Jizong Li1, Shuqing Zhao1, Baotai Zhang1, Jin Huang, Qi Peng, Li Xiao, Xuesong Yuan, Rongli Guo, Jinzhu Zhou, Baochao Fan, Tao Xue, Xuejiao Zhu, Chuanmin Liu, Xing Zhu, Lili Ren*, Bin Li*. A novel recombinant S-based subunit vaccine induces protective immunity against porcine deltacoronavirus challenge in piglets[J]. Journal of Virology, 2023, 97(11): e0095823.
14. Baotai Zhang1, Rongli Guo1, Li Xiao, Chunyan Zhong, Xuesong Yuan, Jin Huang, Xuejiao Zhu, Jinzhu Zhou, Baochao Fan, Tao Xue, Chuanmin Liu, Xing Zhu *, Jizong Li*, Bin Li*. Analysis on the genome of a teschovirus type 1 isolates with swine diarrhea[J]. Heliyon, 2023: e14710.
15. Wei Wang, Baochao Fan, Xuehan Zhang, Rongli Guo, Yongxiang Zhao, Junming Zhou, Jinzhu Zhou, Qi Peng, Mingjun Zhu, Jizong Li*, Bin Li*. Development of a colloidal gold immunochromatographic assay strip using monoclonal antibody for rapid detection of porcine deltacoronavirus[J]. Frontiers in Microbiology, 2023, 5(13): 1074513.
16. Qi Peng1, Wenlong He1, Jizong Li1, Jin Huang, Xuhang Cai, Siyuan Li, Baotai Zhang, Li Xiao, Jie Gao, Chuanhong Wang, Hong Xu, Jiali Qian, Laqiang Gu, Rui Wang, Xuechao Tang, Kemang Li, Xu Song, Jinzhu Zhou, Maojun Liu, Bin Li*. Attenuation of a highly pathogenic porcine deltacoronavirus strain CZ2020 by serial passage in vitro[J]. Transboundary an Emerging Diseases, 2023.
17. Baotai Zhang, Shuqing Zhao, Chunyan Zhong, Tao Xue, Jin Huang, Jinzhu Zhou, Qi Peng, Rongli Guo, Baochao Fan, Chuanmin Liu, Yanxiu Ni, Xing Zhu, Jin Chen, Jizong Li*, Bin Li*. Comparison of pathogenicity of porcine deltacoronavirus CZ2020 from cell culture and intestinal contents in 27-day-old piglets[J]. Microbial Pathogenesis, 2022:105723.
18. Jizong Li, Jinzhu Zhou, Shuqing Zhao, Rongli Guo, Chunyan Zhong, Tao Xue, Qi Peng, Baotai Zhang, Baochao Fan, Chuanmin Liu, Yanxiu Ni, Lili Ren, Xing Zhu, Bin Li*. Pathogenicity, infective dose and altered gut microbiota in piglets infected[J]. Virology, 2022, 567: 26-33.
19. Wei Wang, Jizong Li, Baochao Fan, Xuehan Zhang, Rongli Guo, Yongxiang Zhao, Junming Zhou, Jinzhu Zhou, Dongbo Sun, Bin Li*. Development of a Novel Double Antibody Sandwich ELISA for Quantitative Detection of Porcine Deltacoronavirus Antigen[J]. Viruses, 2021, 13(12): 2403.
20. Qi Wu1, Jizong Li1, Wei Wang1, Jinzhu Zhou, Dandan Wang, Baochao Fan, Xuehan Zhang, Dongbo Sun, Ga Gong*, Sizhu Suolang*, Bin Li*. Next-Generation Sequencing reveals four novel viruses associated with calf diarrhea[J]. Viruses, 2021, 13: 1970.
21. Jizong Li, Leilei Yang, Li Mao, Wenliang Li, Min Sun, Chuanmin Liu, Tao Xue, Wenwen Zhang, Maojun Liu*, Bin Li*. Caprine parainfluenza virus type 3 N protein promotes viral replication via inducing apoptosis[J]. Veterinary Microbiology, 2021, 259:109129.
22. Jizong Li,*, Chuanyan Zhong, Zheng Liao, Li Mao, Wenliang Li, Min Sun, Maojun Liu, Xinqin Ji, Chuanmin Liu, Tao Xue, Leilei Yang, Wenwen Zhang. Bta-miR-98 suppresses replication of caprine parainfluenza virus type 3 through inhibiting apoptosis by targeting caspase-3[J]. Frontiers in Immunology, 2020, 11:1575.
23. Jizong Li,#*, Li Mao #, Fang Xiao, Zheng Liao, Junlei Yin, Wenliang Li, Min Sun, Maojun Liu, Xinqin Ji, Chuanmin Liu, Tao Xue, Leilei Yang, Wenwen Zhang. Interferon stimulated genes inhibit caprine parainfluenza virus type 3 replication in MDBK cells[J]. Veterinary Microbiology, 2020, 241: 108573.
24. Chuanyan Zhong, Jizong Li*, Li Mao, Maojun Liu, Xing Zhu, Wenliang Li, Min Sun, Xinqin Ji, Fang Xiao, Leilei Yang, Wenwen Zhang, Zheng Liao. Proteomics analysis reveals heat shock proteins involved in caprine parainfluenza virus type 3 infection[J]. BMC Veterinary Research, 2019, 15:151.
25. Tao Xue#, Jizong Li#, Chuanmin Liu. A radical form of nitric oxide inhibits porcine circovirus type 2 replication in vitro[J]. BMC Veterinary Research, 2019, 15(1):47.
26. Jizong Li, Li Mao, Chuanyan Zhong, Wenliang Li, Fei Hao, Min Sun, Xing Zhu, Xinqin Ji, Fang Xiao, Leilei Yang, Wenwen Zhang, Maojun Liu. Cellular microRNA bta-miR-222 suppresses caprine parainfluenza virus type 3 replication via downregulation of interferon regulatory factor 2[J]. Veterinary Microbiology, 2018, 224: 58-65.
27. Jizong Li, Li Mao, Wenliang Li, Fei Hao, Chuanyan Zhong, Xing Zhu, Xinqin Ji, Leilei Yang, Wenwen Zhang, Maojun Liu, Jieyuan Jiang. Analysis of microRNAs Expression Profiles in Madin-Darby Bovine Kidney Cells Infected With Caprine Parainfluenza Virus Type 3[J]. Frontiers in Cellular and Infection Microbiology, 2018, 8:93.
28. Jizong Li, Wenliang Li, Li Mao, Fei Hao, Leilei Yang, Wenwen Zhang, Jieyuan Jiang. Rapid detection of novel caprine parainfluenza virus type 3 (CPIV3) using a TaqMan-based RT-qPCR[J]. Journal of Virological Methods, 2016, 236: 126-131.
29. Jizong Li, Tianqi Yu, Feipeng Zhang, Xiaobo Wang, Jinzhu Zhou, Xing Gao, Song Gao, Xiufan Liu. Inactivated chimeric porcine circovirus (PCV) 1-2 vaccines based on genotypes 2b and 2d exhibit similar immunological effectiveness in protecting pigs against challenge with PCV2b strain 0233[J]. Archives of Virology, 2016:1-12.
30. Jizong Li, Tianqi Yu, Xiaobo Wang, Jinzhu Zhou, Ruxia Gao, Feipeng Zhang, Xing Gao, Song Gao, Xiufan Liu. Comparative efficacy of experimental inactivated and live-attenuated chimeric porcine circovirus (PCV) 1-2b vaccines derived from PCV1 and PCV2b isolates originated in China[J]. Virology Journal, 2015, 12: 113-124.
31. Jizong Li, Tianqi Yu, Jinzhu Zhou, Wei Tu, Song Gao, Xiufan Liu. Optimal transfection methods and comparison of PK-15 and Dulac cells for rescue of chimeric porcine circovirus type 1-2[J]. Journal of Virological Methods, 2014, 208:90-95.
32. 易鑫，袁雪松，李基棕*，李彬*，贡嘎*, 等. 猪传染性胃肠炎病毒、猪流行性腹泻病毒、猪δ冠状病毒三联灭活疫苗的安全性和免疫持续期研究[J]. 畜牧与兽医, 2025，57（05）: 93-98.
33. 陈琢琦，范丽原，李基棕*，李彬*，袁晓民*, 等. 转录因子CEBPB对猪δ冠状病毒体外复制的抑制作用[J]. 畜牧兽医学报, 2025，56(07)：3423-3432.
34. 李思远1，付新成1，张琪*，李基棕*，李彬*, 等.*河北省廊坊市牛主要病毒性腹泻病原感染状况检测及牛冠状病毒演化分析[J]. 畜牧兽医学报, 2024，55 (2)：649-659.
35. 张宝太1，李基棕*，李彬*, 等. 猪δ冠状病毒结构蛋白的表达及其多克隆抗体的制备[J]. 畜牧与兽医, 2023. 55 (8): 86-92.
36. 黄金，李基棕*，李彬*, 等.牛冠状病毒TaqMan荧光定量检测方法的建立及国内部分地区流行病学调查[J]. 江苏农业科学, 2023. 51 (17): 29-33.
37. 肖丽1，张宝太1，李基棕*，李彬*, 等. TGEV SHXB株组织毒对1月龄仔猪的致病性研究[J]. 中国动物传染病学报, 2023.
38. 赵淑庆1，张宝太1，李基棕*，李彬*, 等. 乙肝核心抗原嵌合PEDV S1抗原表位病毒样颗粒疫苗的免疫原性评价[J]. 中国动物传染病学报学报, 2021.
39. 廖 政, 嵇辛勤*, 李基棕*, 等. Bta-miR-677靶向线粒体抗病毒信号蛋白影响Ⅰ型干扰素的生成[J]. 畜牧兽医学报, 2020, 51 (1): 150-158.
40. 肖 芳, 嵇辛勤*, 李基棕*, 等. 山羊副流感病毒3型感染MDBK细胞和BECs后7种ISGs mRNA变化分析[J]. 中国预防兽医学报, 2019, (11): 1147-1153.
41. 廖 政, 李基棕*, 肖 芳, 等. 山羊副流感病毒3型通过Caspase 3途径诱导气管上皮细胞凋亡[J]. 畜牧兽医学报, 2019, 50 (10): 2061-2069.
42. 钟纯燕, 郝飞, 李文良, 毛立, 主性, 嵇辛勤, 江杰元, 李基棕*, 刘茂军. 不同消毒剂对规模化养羊场舍内空气细菌的影响[J].江苏农业科学, 2019,47(08):194-197.
43. 李基棕, 张冬霞, 李丽, 薛涛, 刘传敏. NO自由基对猪圆环病毒2型复制的体外抑制作用研究[J]. 中国畜牧兽医, 2019, 46(3):924-930.
44. 钟纯燕, 李基棕*，毛立, 李文良，郝飞，孙敏，刘茂军，主性，嵇辛勤，肖芳，杨蕾蕾，张纹纹. 山羊副流感病毒3型感染MDBK细胞的转录组分析[J]. 畜牧兽医学报, 2019(2) :364-372.
45. 钟纯燕, 李基棕*，毛立, 李文良，郝飞，孙敏，刘茂军，主性，嵇辛勤，肖芳，杨蕾蕾，张纹纹. MiR-222对山羊副流感病毒3型复制的影响[J]. 畜牧兽医学报, 2018(12) :2664-2671.
46. 钟纯燕，主性*，李基棕*，毛立，李文良，郝飞，刘茂军，嵇辛勤，肖芳. 慢病毒介导的bta-miR-222稳定过表达MDBK细胞株的构建及鉴定[J].中国兽医科学, 2019(1):50-57.
47. 李基棕，李文良，毛立，郝飞，杨蕾蕾，张纹纹，江杰元. 伪结核棒状杆菌的分离鉴定及病原性研究[J]. 江苏农业科学, 2018, 46(4):158-162.
48. 李基棕，李文良，毛立，郝飞，杨蕾蕾，张纹纹，江杰元. 1株绵羊溶血性曼氏杆菌的分离鉴定及致病性研究[J]. 江苏农业科学, 2017, 45(7):156-158.
49. 李基棕，李文良，毛立，郝飞，杨蕾蕾，张纹纹，江杰元. 山羊副流感病毒3型感染MDBK细胞的miRNA表达谱变化分析[J]. 畜牧兽医学报, 2017, 48(5): 896-906.
（三）获奖情况
1. 李彬, 周斌, 范宝超, 周金柱, 郭容利, 粟硕, 任丽莉, 赵永祥, 李基棕，汪伟. 猪重要病毒侵染宿主细胞的分子机制，江苏省科学技术奖二等. 2024年.
2. 毛立，郝飞，李文良，王金兰，李基棕，杨蕾蕾，陆宏辉，刘茂军，孙敏，程子龙，张晓曦，许新松，董易春，窦永喜，江杰元. 江苏省肉羊主要疫病病原学及防控技术研究与应用. 江苏省畜牧兽医学会科技奖. 2022年.
3. 李文良，毛 立，李基棕，杨蕾蕾，郝 飞，张纹纹，孙 敏，程子龙，刘茂军，江杰元，陆宏辉，丁永龙，顾拥建，张则斌，王振华. 山羊副流感病毒3型病原学与防控技术研究. 江苏省农学会科技奖. 2021年.
4. 李文良，毛立，李基棕，杨蕾蕾，郝飞，张纹纹，孙敏，江杰元，刘茂军. 山羊副流感病毒3型的发现及病原学研究. 江苏省农业科学院. 江苏省农业科学院科学技术奖二等. 2020年.
5. 高崧，刘秀梵，何海蓉，郇长超，高清清，王小波，高如一，何洪波，李基棕，樊铭玉. 嵌合型猪圆环病毒活疫苗（C1-233株）的研制. 北京大北农科技集团股份有限公司. 第十一届大北农科技奖动物医学类. 2019年.
（四）新兽药
1. 猪δ冠状病毒灭活疫苗（LYG/14株）临床试验批件（批件号：2023012）。
2. 猪传染性胃肠炎、猪流行性腹泻、猪δ冠状病毒三联灭活疫苗（SHXB株+ZJ/15株+LYG/14株）临床试验批件（批件号：2023036）。