于岩飞，博士，副研究员。南京农业大学、江苏大学、湖南农业大学研究生导师，国际支原体组织成员，江苏省免疫学会会员。

主要研究领域和方向：动物呼吸道病原尤其是支原体的致病机制、免疫逃逸机制及防控技术研究，动物病原尤其是非洲猪瘟病毒新型检测方法及疫苗的开发。近年来，先后主持了国家自然科学基金项目、中澳青年科学家交流计划、中国博士后科学基金项目、江苏省农业科技自主创新资金、江苏省博士后资助计划等，参加了国家重点研发专项等项目。发表论文20余篇，其中以第一作者在Virulence，Veterinary Research，Journal of Proteomics，Frontiers in Microbiology等杂志发表SCI论文7篇；获国家发明专利授权1项；参编专著1部；培养硕士研究生2名。

一、主持或参加的科研项目：

1. 科技部，国家重点研发计划“政府间国际科技创新合作”重点专项，2019YFE0107300，非洲猪瘟早期诊断试剂及亚单位疫苗研发，2020/07-2023/06，787万元，参加。

2. 科技部，“中澳青年科学家交流计划”，2020，主持。

3. 江苏省农业科技自主创新资金，“基于CRISPR/Cas9系统的猪肺炎支原体基因缺失疫苗株的构建及其免疫保护性分析”，CX(20)3090，30万元，2020/08-2022/07，主持。

4. 国家自然科学基金青年科学基金项目,“肌醇代谢参与猪肺炎支原体致病的机制解析”，31800161，25万元，2019/01-2021/12，参加。

5. 中国博士后科学基金学术交流项目，“博士后国际交流计划”，90011802，3万元，2018，主持。

6. 国家自然科学基金青年科学基金项目，“猪肺炎支原体EF-Tu劫持H因子逃避宿主补体旁路途径激活机制研究”，31700158，24万元，2018/01-2020/12，主持。

7. 江苏省博士后科研资助计划A类，1701004A，6万元，2017/01-2018/07，主持。

8. 江苏省博士后日常资助计划，2万元，2017/01-2018/07，主持。

9. 国家自然科学基金优秀青年科学基金项目，31322054，动物病原细菌，100万元，2014/01-2016/12，参加。

二、发表主要论文

1. Yanfei Yu, Jia Wang, Rui Han, Li Wang, Lei Zhang, Amy Yimin Zhang, Jiuqing Xin, Shaoli Li, Yanhua Zeng, Guoqing Shao, Zhixin Feng*, Qiyan Xiong*. Mycoplasma hyopneumoniae evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu). Virulence, 2020 Aug 20; 11(1): 1059-1074.

2. Rong Chen^#, Yanfei Yu^#, Zhixin Feng, Rong Gan, Xing Xie, Zhenzhen Zhang, Qingyun Xie, Weiwu Wang, Tingting Ran*, Wei Zhang*, Qiyan Xiong* , Guoqing Shao. Featured species-specific loops are found in the crystal structure of Mhp Eno, a cell surface adhesion from Mycoplasma hyopneumoniae. Frontiers in Cellular and Infection Microbiology, 2019 Jun 13; 9: 209.

3. Yanfei Yu, Maojun Liu, Lizhong Hua, Mingjun Qiu, Wei Zhang, Yanna Wei, Yuan Gan, Zhixin Feng, Guoqing Shao, Qiyan Xiong*. Fructose-1,6-bisphosphate aldolase encoded by a core gene of Mycoplasma hyopneumoniae contributes to host cell adhesion. Veterinary Research, 2018 Nov 19; 49 (1): 114.

4. Yanfei Yu, Yunyun Qian, Dechao Du, Quan Li, Chenyang Xu, Hanze Liu, Mianmian Chen, Huochun Yao, Chengping Lu, Wei Zhang*. Infection and adaption-based proteomic changes of Streptococcus suis serotype 2 in a pig model. Journal of Proteomics, 2018 May 30; 180: 41-52.

5. Yanfei Yu, Hongen Wang, Jia Wang, Zhixin Feng, Meng Wu, Beibei Liu, Jiuqing Xin, Qiyan Xiong*, Maojun Liu*, Guoqing Shao. Elongation factor thermo unstable (EF-Tu) moonlights as an adhesin on the surface of Mycoplasma hyopneumoniae by binding to fibronectin. Frontiers in Microbiology, 2018 May 15; 9: 974.

6. Yanfei Yu, Yunyun Qian, Dechao Du, Chenyang Xu, Chen Dai, Quan Li, Hanze Liu, Jing Shao, Zongfu Wu, Wei Zhang*. SBP2 plays an important role in virulence changes of different artificial mutants of Streptococcus suis. Molecular BioSystems, 2016 May 24; 12(6):1948-62.

7. Yanfei Yu, Guangyan Wu, Zhipeng Zhai, Huochun Yao, Chengping Lu, Wei Zhang*. Fifteen novel immunoreactive proteins of Chinese virulent Haemophilus parasuis serotype 5 verified by an immunoproteomic assay. Folia Microbiologica (Praha), 2015 Jan; 60(1): 81-7.

8. Genglin Guo, Dechao Du, Yanfei Yu, Yuhang Zhang, Yunyun Qian, Wei Zhang*. Pan-genome analysis of Streptococcus suis serotype 2 revealed genomic diversity among strains of different virulence. Transbound Emerg Dis. 2020 Jul 11.

9. 华利忠，王世杰，马丹夫，刘茂军，冯志新，刘蓓蓓，韦艳娜，于岩飞，邵国青*. 猪肺炎支原体醛缩酶原核表达及致猪气管上皮细胞凋亡的研究. 动物医学进展. 2019, 40 (6): 17-22.

10. Xing Xie, Yuan Gan, Maoda Pang, Guoqing Shao, Lei Zhang, Beibei Liu, Qi Xu, Haiyan Wang, Yanyan Feng, Yanfei Yu, Rong Chen, Meng Wu, Zhenzhen Zhang, Lizhong Hua, Qiyan Xiong, Maojun Liu, Zhixin Feng*. Establishment and characterization of a telomerase-immortalized porcine bronchial epithelial cell line. J Cell Physiol. 2018 Dec; 233 (12): 9763-9776.

11. 张珍珍，韦艳娜，王佳，于岩飞，冯志新，邵国青，熊祺琰*. 皂树皂苷QS21增强猪支原体肺炎活疫苗滴鼻免疫小鼠效果评价. 中国兽药杂志, 2018, (12): 24-29.

12. Yunyun Qian, Yuhang Zhang, Yanfei Yu, Quan Li, Genglin Guo, Yang Fu, Huo chun Yao, Chengping Lu, Wei Zhang*. SBP1 is an adhesion-associated factor without the involvement of virulence in Streptococcus suis serotype 2. Microb Pathog. 2018 Sep; 122: 90-97.

13. Quan Li, Yuhang Zhang, Dechao Du, Yanfei Yu, Wei Zhang*. Characterization and functional analysis of PnuC that is involved in the oxidative stress tolerance and virulence of Streptococcus suis serotype 2. Vet Microbiol. 2018 Mar; 216: 198- 206.

14. Quan Li, Yang Fu, Yanan He, Yuhang Zhang,Yunyun Qian, Yanfei Yu, Huochun Yao, Chengping Lu, Wei Zhang*. Fibronectin /fibrinogen-binding protein (FBPS) is not a critical virulence factor for the Streptococcus suis serotype 2 strain ZY05719. Vet Microbiol. 2017 Sep; 208: 38-46.

15. Quan Li, Yang Fu, Caifeng Ma, Yanan He, Yanfei Yu, Dechao Du, Huochun Yao, Chengping Lu, Wei Zhang*. The non-conserved region of MRP is involved in the virulence of Streptococcus suis serotype 2. Virulence. 2017 Mar 31:0.

16. Quan Li, Caifeng Ma, Yang Fu, Yanan He, Yanfei Yu, Dechao Du, Huochun Yao, Chengping Lu, Wei Zhang*. Factor H specifically capture novel Factor H-binding proteins of Streptococcus suis and contribute to the virulence of the bacteria. Microbiological Research. 2017, 196: 17-25.

17. 杜德超，于岩飞，马彩凤，姚火春，陆承平，张炜*. 猪链球菌2型不同mrp基因型与毒力的关系. 微生物学通报. 2016, 43 (01).

18. Quan Li, Hanze Liu, Dechao Du, Yanfei Yu, Caifeng Ma, Fangfang Jiao, Huochun Yao, Chengping Lu, Wei Zhang*. Identification of Novel Laminin- and Fibronectin-binding Proteins by Far-Western Blot: Capturing the Adhesins of Streptococcus suis Type 2. Frontiers in Cellular and Infection Microbiology. 2015, 5: 82.

19. 吴光燕，于岩飞，叶琳璐，张炜*. 猪链球菌2型新型毒力调控因子RfeA的研究. 畜牧与兽医. 2015, 47 (04).

20. Zhipeng Zhai, Xingxing Li, Xi Xiao, Jing Yu, Mianmian Chen, Yanfei Yu, Guangyan Wu, Yanzhe Li, Linlu Ye, Huochun Yao, Chengping Lu, Wei Zhang*. Immunoproteomics selection of cross-protective vaccine candidates from Riemerella anatipestifer serotypes 1 and 2. Veterinary Microbiology. 2013, 162 (2-4): 850-7.

三、参编著作

《支原体感染实验室诊断技术》. 人民卫生出版社：北京，2019.

四、获得荣誉

1. 国际支原体组织博士后奖，2018.

2. “猪链球菌2型蛋白的差异表达及翻译后修饰对其毒力的影响”，南京农业大学优秀博士学位论文，2017.

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